SIGLEC8 Antibody

Primary Antibodies

Blue Ice

54 kDa

Sialic acid-binding immunoglobulin (Ig)-like lectins, or
SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1
transmembrane proteins each having a unique expression pattern,
mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like
subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have
2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor
tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a
motif homologous to one identified in signaling lymphocyte
activation molecule (SLAM; MIM 603492) that mediates an association
with SLAM-associated protein (SAP; MIM 300490) (summarized by
Foussias et al., 2000 [PubMed 11095983]).

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This SIGLEC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the N-terminal region of human SIGLEC8.

Sialic acid-binding Ig-like lectin 8

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.