EWSR1 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

This gene encodes a multifunctional protein that is
involved in various cellular processes, including gene expression,
cell signaling, and RNA processing and transport. The protein
includes an N-terminal transcriptional activation domain and a
C-terminal RNA-binding domain. Chromosomal translocations between
this gene and various genes encoding transcription factors result
in the production of chimeric proteins that are involved in
tumorigenesis. These chimeric proteins usually consist of the
N-terminal transcriptional activation domain of this protein fused
to the C-terminal DNA-binding domain of the transcription factor
protein. Mutations in this gene, specifically a t(11; 22)(q24; q12)
translocation, are known to cause Ewing sarcoma as well as
neuroectodermal and various other tumors. Alternative splicing of
this gene results in multiple transcript variants. Related
pseudogenes have been identified on chromosomes 1 and 14. [provided
by RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Mouse

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.