WWOX Antibody

Primary Antibodies

Blue Ice

47 kDa

WW domain-containing proteins are found in all eukaryotes
and play an important role in the regulation of a wide variety of
cellular functions such as protein degradation, transcription, and
RNA splicing. This gene encodes a protein which contains 2 WW
domains and a short-chain dehydrogenase/reductase domain (SRD). The
highest normal expression of this gene is detected in hormonally
regulated tissues such as testis, ovary, and prostate. This
expression pattern and the presence of an SRD domain suggest a role
for this gene in steroid metabolism. The encoded protein is more
than 90% identical to the mouse protein, which is an essential
mediator of tumor necrosis factor-alpha-induced apoptosis,
suggesting a similar, important role in apoptosis for the human
protein. In addition, there is evidence that this gene behaves as a
suppressor of tumor growth. Alternative splicing of this gene
generates transcript variants that encode different isoforms.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This WWOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-396 amino acids from the C-terminal region of human WWOX.

WW domain-containing oxidoreductase

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.