VDR Antibody

Primary Antibodies

Blue Ice

48 kDa

This gene encodes the nuclear hormone receptor for vitamin
D3. This receptor also functions as a receptor for the secondary
bile acid lithocholic acid. The receptor belongs to the family of
trans-acting transcriptional regulatory factors and shows sequence
similarity to the steroid and thyroid hormone receptors. Downstream
targets of this nuclear hormone receptor are principally involved
in mineral metabolism though the receptor regulates a variety of
other metabolic pathways, such as those involved in the immune
response and cancer. Mutations in this gene are associated with
type II vitamin D-resistant rickets. A single nucleotide
polymorphism in the initiation codon results in an alternate
translation start site three codons downstream. Alternative
splicing results in multiple transcript variants encoding the same
protein.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This VDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-299 amino acids from the Central region of human VDR.

Vitamin D3 receptor

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.