SSX4 Antibody

Primary Antibodies

Blue Ice

22 kDa

The product of this gene belongs to the family of highly
homologous synovial sarcoma X (SSX) breakpoint proteins. These
proteins may function as transcriptional repressors. They are also
capable of eliciting spontaneously humoral and cellular immune
responses in cancer patients, and are potentially useful targets in
cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have
been involved in the t(X; 18) translocation characteristically found
in all synovial sarcomas. This translocation results in the fusion
of the synovial sarcoma translocation gene on chromosome 18 to one
of the SSX genes on chromosome X. Chromosome Xp11 contains a
segmental duplication resulting in two identical copies of synovial
sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail
orientation. This gene, SSX4B, represents the more centromeric
copy. Two transcript variants encoding distinct isoforms have been
identified for this gene.

None

batch dependent

For WB starting dilution is: 1:1000

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.