SFTPB Antibody

Primary Antibodies

Blue Ice

42 kDa

SFTPB is the pulmonary-associated surfactant
protein B (SPB), an amphipathic surfactant protein essential for
lung function and homeostasis after birth. Pulmonary surfactant is
a surface-active lipoprotein complex composed of 90% lipids and 10%
proteins which include plasma proteins and apolipoproteins SPA,
SPB, SPC and SPD. The surfactant is secreted by the alveolar cells
of the lung and maintains the stability of pulmonary tissue by
reducing the surface tension of fluids that coat the lung. The SPB
enhances the rate of spreading and increases the stability of
surfactant monolayers in vitro. Multiple mutations in this gene
have been identified, which cause pulmonary surfactant metabolism
dysfunction type 1, also called pulmonary alveolar proteinosis due
to surfactant protein B deficiency, and are associated with fatal
respiratory distress in the neonatal period. Alternatively spliced
transcript variants encoding the same protein have been identified.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This SFTPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the Central region of human SFTPB.

Pulmonary surfactant-associated protein B

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.