PABPC4 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail
present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or
IPABP (inducible PABP) was isolated as an activation-induced T-cell
mRNA encoding a protein. Activation of T cells increased PABPC4
mRNA levels in T cells approximately 5-fold. PABPC4 contains 4
RNA-binding domains and proline-rich C terminus. PABPC4 is
localized primarily to the cytoplasm. It is suggested that PABPC4
might be necessary for regulation of stability of labile mRNA
species in activated T cells. PABPC4 was also identified as an
antigen, APP1 (activated-platelet protein-1), expressed on
thrombin-activated rabbit platelets. PABPC4 may also be involved in
the regulation of protein translation in platelets and
megakaryocytes or may participate in the binding or stabilization
of polyadenylates in platelet dense granules. Alternatively spliced
transcript variants encoding different isoforms have been found for
this gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This PABPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human PABPC4.

Polyadenylate-binding protein 4

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.