SAFB Antibody

Rabbit Ig

Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

This gene encodes a DNA-binding protein that has highspecificity for scaffold or matrix attachment region DNA elements(S/MAR DNA). This protein is thought to be involved in attachingthe base of chromatin loops to the nuclear matrix but there isconflicting evidence as to whether this protein is a component ofchromatin or a nuclear matrix protein. Scaffold attachment factorsare a specific subset of nuclear matrix proteins (NMP) thatspecifically bind to S/MAR. This encoded protein is thought toserve as a molecular base to assemble a 'transcriptosome complex'in the vicinity of actively transcribed genes. It is involved inthe regulation of the heat shock protein 27 transcription and alsocan act as an estrogen receptor corepressor. This gene is acandidate gene for breast tumorigenesis.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Polyclonal

Homo sapiens