MBD4 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

DNA methylation is the major modification of eukaryotic
genomes and plays an essential role in mammalian development. Human
proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of
nuclear proteins related by the presence in each of a methyl-CpG
binding domain (MBD). Each of these proteins, with the exception of
MBD3, is capable of binding specifically to methylated DNA. MBD4
may function to mediate the biological consequences of the
methylation signal. In addition, MBD4 has protein sequence
similarity to bacterial DNA repair enzymes and thus may have some
function in DNA repair. Further, MBD4 gene mutations are detected
in tumors with primary microsatellite-instability (MSI), a form of
genomic instability associated with defective DNA mismatch repair,
and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.

None

batch dependent

For WB starting dilution is: 1:1000

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.