Mouse Irf3 Antibody

ArtNr	PRS-60-856-400ul
Hersteller	ProSci
Menge	400 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Western Blot Proliferation Primary Antibodies By Organ Lung Cancer Bladder Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Marichal, T., et al. J. Allergy Clin. Immunol. 126(4):836-844(2010) Menachery, V.D., et al. J. Virol. 84(19):9685-9694(2010) Carrigan, S.O., et al. J. Immunol. 185(6):3602-3609(2010) Wang, J., et al. J. Immunol. 185(3):1720-1729(2010)
NCBI	Irf3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Interferon regulatory factor 3, IRF-3, Irf3
Lieferbar
Manufacturer - Applications	For WB starting dilution is: 1:1000
Manufacturer - Isotype	Rabbit Ig
Shipping Temperature	blue ice or room temperature
Storage Conditions	Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	47 kDa
Manufacturer - Research Area	Immunology
Background	Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration	Batch dependent
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: Bovine, Pig
Immunogen	This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Clonality	Polyclonal
NCBI Official Name	Interferon regulatory factor 3
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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Lieferung vsl. bis 02.10.2025

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