FBXW4 Antibody

Primary Antibodies

Blue Ice

46 kDa

This gene is a member of the F-box/WD-40 gene family,
which recruit specific target proteins through their WD-40
protein-protein binding domains for ubiquitin mediated degradation.
In mouse, a highly similar protein is thought to be responsible for
maintaining the apical ectodermal ridge of developing limb buds;
disruption of the mouse gene results in the absence of central
digits, underdeveloped or absent metacarpal/metatarsal bones and
syndactyly. This phenotype is remarkably similar to split
hand-split foot malformation in humans, a clinically heterogeneous
condition with a variety of modes of transmission. An autosomal
recessive form has been mapped to the chromosomal region where this
gene is located, and complex rearrangements involving duplications
of this gene and others have been associated with the condition. A
pseudogene of this locus has been mapped to one of the introns of
the BCR gene on chromosome 22.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.

F-box/WD repeat-containing protein 4

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.