KIR2DS3 Antibody

Primary Antibodies

Blue Ice

34 kDa

Killer cell immunoglobulin-like receptors (KIRs) are
transmembrane glycoproteins expressed by natural killer cells and
subsets of T cells. The KIR genes are polymorphic and highly
homologous and they are found in a cluster on chromosome 19q13.4
within the 1 Mb leukocyte receptor complex (LRC). The gene content
of the KIR gene cluster varies among haplotypes, although several
'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,
KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of
extracellular immunoglobulin domains (2D or 3D) and by whether they
have a long (L) or short (S) cytoplasmic domain. KIR proteins with
the long cytoplasmic domain transduce inhibitory signals upon
ligand binding via an immune tyrosine-based inhibitory motif
(ITIM), while KIR proteins with the short cytoplasmic domain lack
the ITIM motif and instead associate with the TYRO protein tyrosine
kinase binding protein to transduce activating signals. The ligands
for several KIR proteins are subsets of HLA class I molecules;
thus, KIR proteins are thought to play an important role in
regulation of the immune response.

None

batch dependent

For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.