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CD357 Antibody [DTA-1]

CD357 Antibody [DTA-1]

ArtNr	PRS-76-983-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Food Safety Drugs Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Immunohistochemistry Immunofluorescence Primary Antibodies
Typ	Antibody Monoclonal
Format	liquid
Applikationen	FC, IF, IHC
Clon	DTA-1
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b
Konjugat/Tag	Unconjugated
Citations	Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., ... Sakaguchi, S. (2005). Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+ CD25+ CD4+ regulatory T cells.The Journal of experimental medicine,202(7), 885-891. Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S. (2002). Stimulation of CD25+ CD4+ regulatory T cells through GITR breaks immunological self-tolerance.Nature immunology,3(2), 135-142. Tone, M., Tone, Y., Adams, E., Yates, S. F., Frewin, M. R., Cobbold, S. P., Waldmann, H. (2003). Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.Proceedings of the National Academy of Sciences,100(25), 15059-15064.
NCBI	Tnfrsf18
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	AITR, Gitr, Tnfrsf18
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Manufacturer - Isotype	Rat IgG2b
Shipping Temperature	blue ice or room temperature
Storage Conditions	The product should be stored undiluted at 4°C . Do not freeze.
Manufacturer - Research Area	Immunology, Functional Assays
Background	The DTA-1 monoclonal antibody specifically reacts with MouseGlucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in naïve mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration	Batch dependent
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Clonality	Monoclonal
NCBI Official Name	tumor necrosis factor receptor superfamily, member 18
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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Lieferung vsl. bis 04.09.2025

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