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B7-H3 Detection Set (Risk Free)

ArtNr PRS-RF16090-1Set
Hersteller ProSci
Menge 1 Set
Kategorie
Typ Antibody Monoclonal
Format Liquid
Applikationen WB, FC, IF, ICC, ELISA, IHC-P
Specific against Human (Homo sapiens)
Isotype IgG1
Konjugat/Tag Unconjugated
Citations Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2:269-74.
Sun M, Richards S, Prasad DV, et al. Characterization of mouse and human B7-H3 genes. J Immunol 2002; 168:6294-7.
Yi KH and Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 2009; 229:145-51.
Wang L, Kang FB, and Shan BE. B7-H3-mediated tumor immunology: friend or foe?. Int J Cancer 2014; 134:2764-71.
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Lieferbar
Storage Conditions
Antibodies can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Background
B7-H3 Antibody: CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers. ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications
Set Contents
B7-H3 Antibody [2H5], Cat. No. RF16091 (20 μg)

B7-H3 Antibody [2A7], Cat. No. RF16092 (20 μg)
B7-H3 Antibody [4H3], Cat. No. RF16093 (20 μg)
B7-H3 Antibody [7B3], Cat. No. RF16094 (20 μg)
B7-H3 Antibody [10G6], Cat. No. RF16095 (20 μg)
Purification
Antibodies are supplied as protein A purified IgG1
Concentration
Antibody 1 mg/mL
Buffer
PBS containing 0.02% sodium azide.
Immunogen
B7-H3 antibodies were raised against the extracellular domain of human B7-H3
Clonality
Monoclonal
Disclaimer
This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1 Set
Lieferbar: In stock
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