PDL1 ELISA Matched Antibody Pair (Risk Free)

Detection Sets

Dry Ice

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts.

ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein.
Validated for flow cytometry and ELISA
Rigorously tested for the following applications:
Immunoblot
Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Multiple antibodies per target allowing the user to choose the best antibody for their application
Available individually or as a set
Risk-FreeTM means they are guaranteed to work for their approved applications

Mouse Monoclonal: Antibodies supplied as protein A purified IgG1.

Single Domain: Antibodies supplied as affinity chromatography purified via nickel column.

PBS containing 0.02% sodium azide.

Monoclonal

Optimal dilutions for each application to be determined by the researcher.