Anti-SUMO-1 Mouse mAb  (C-terminal)

Primary Antibodies

SUMO-1

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

Small ubiquitin-related modifier 1, 2, and 3 (SUMO-1, 2, and 3) are members of the ubiquitin-like protein family. Similar to ubiquitin, SUMO proteins bind to target proteins through a post-translational modification system. SUMO-1 can be covalently attached to target proteins through the formation of an isopeptide bond between its C-terminal Gly97 and a lysine residue in the target protein. This process is important for regulating nuclear trafficking, formation of subnuclear structures, transcriptional activity, and protein stability, with SUMO-1 being conjugated to proteins such as RanGAP, PML, p53 and IκB-α.

Anti-SUMO-1 Mouse mAb (C-terminal) detects endogenous levels of SUMO-1 but not SUMOylated proteins.

Unmodified

Monoclonal

Nucleus, Cytoplasm