Anti-Crotonyl-Histone H4 (Lys8) Rabbit mAb

Primary Antibodies

Histone H4

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine crotonylation is highly conserved in eukaryotic cellsfrom worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Crotonylation of histone H4 at Lys8 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.

PBS, Glycerol, BSA

Lys8

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine crotonylation is highly conserved in eukaryotic cellsfrom worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Crotonylation of histone H4 at Lys8 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.