Anti-CDK8 Rabbit mAb

ArtNr	PTM-5741
Hersteller	PTM Biolabs
Menge	100 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Lyophilized powder
Applikationen	WB, IHC-P
Clon	JRMR-10371-16
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cyclin-dependent kinase 8
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	CDK8
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Cell Biology, Immunology
Product description	Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and gene-specific transcription factors, which can activate and inhibit transcription. In addition, CDK8 can activate a variety of signal transduction pathways such as Wnt/β-catenin and Notch, thereby inducing the occurrence and metastasis of malignant tumors such as rectal cancer and melanoma. Recent studies have found that blocking the activity of CDK8 gene can greatly reduce the glucose utilization rate of cancer cells.
Purification Method	Protein A purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Recombinant Monoclonal
Background	Cyclin-dependent kinase 8 (CDK8) is a cell cycle regulator, which can activate cyclin C, act in the G1/S phase, and regulate the normal cell cycle. CDK8 together with Cyclin, Med12 and Med13 form an intermediary complex, which is widely involved in the transmission of information between RNA polymerase II and gene-specific transcription factors, which can activate and inhibit transcription. In addition, CDK8 can activate a variety of signal transduction pathways such as Wnt/β-catenin and Notch, thereby inducing the occurrence and metastasis of malignant tumors such as rectal cancer and melanoma. Recent studies have found that blocking the activity of CDK8 gene can greatly reduce the glucose utilization rate of cancer cells.
Cellular Localization	Nucleus

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Menge: 100 ul

lieferbar

Lieferung vsl. bis 25.09.2025