Anti-Phospho-4E-BP1 (Thr37/46) Rabbit mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex. The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Besides, 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.

PBS, Glycerol, BSA

Thr37, Thr46

Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex. The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Besides, 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.