Anti-Desmin Rabbit mAb

Organelle Marker Antibodies

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

Desmin is the main intermediate filament protein in skeletal and cardiac muscle cells and is essential for both the structural integrity and the survival of muscle cells. As an abundant muscle-specific protein, desmin has been widely used as a marker of muscle derived tumors. Anti-desmin is also valuable in the differential diagnosis of tumors of uncertain origin. Desmin is a myogenic marker expressed in early development that forms a network of filaments that extends across the myofibril and surrounds Z discs. Desmin knockout mice develop cardiomyopathy, skeletal and smooth muscle defects. In human, desmin related myopathies might be caused by mutations in the corresponding desmin gene or in proteins with which desmin interacts, including αB-crystallin and synemin.

PBS, Glycerol, BSA

Recombinant Monoclonal

Sarcolemma, cytoplasm, nucleus