Hersteller |
AssaySolution
|
Typ |
Elisa-Kit |
Specific against |
Hu |
Applikationen |
ELISA |
Menge |
1Kit |
ArtNr |
AYQ-E11129 |
eClass 6.1 |
32160605 |
eClass 9.0 |
32160605 |
Lieferbar |
|
Storage |
Store the unopened product at 2 - 8C C. Protect from light. Do not use past expiration date. |
Gene ID |
5133 |
Gene Symbol |
PD-1 |
Specificity |
This assay has high sensitivity and excellent specificity for detection of human PD-1. No significant cross-reactivity or interference between human PD-1 and analogues was observed. |
Kit Components |
Assay plate (12 x 8 coated Microwells), Standard (Freeze dried), Biotin-antibody (60 x concentrate), HRP-avidin (20 x concentrate), Biotin-antibody Diluent, HRP-avidin Diluent, Sample Diluent, Wash Buffer (20 x concentrate), TMB Substrate, Stop Solution, Adhesive Strip (For 96 wells), Instruction manual |
Notes |
Please contact our Technical Services with any questions regarding species reactivity |
Standard Curve Range |
156 pg/ml - 10000 pg/ml |
Sensitivity |
125 pg/ml |
Inter Assay |
CV%<10% |
Intra Assay |
CV%<8% |
Assay Type |
Sandwich ELISA |
Suitable Sample Type |
serum, plasma, tissue homogenates, cell lysate, cell culture medium. |
Sample Volume |
50-100ul |
Typical Data |
ELISA: Human PD-1 ELISA Kit (Colorimetric) - These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. |
Background |
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-1 inhibitors, a new class of drugs that block PD-1, activate the immune system to attack tumors and are used to treat certain types of cancer. |
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