Anti-IRAK-4 Antibody (Phospho-Thr345) (OAAI00415)

ca.51 kDa

51135

IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of Interleukin-1 (IL-1) induced activation of the NFkappaB pathway. IL-1 stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor, where IRAK is phosphorylated, ubiquitinated, and eventually degraded. There are four members (IRAK1, IRAK2, IRAK3/IRAK-M and IRAK4). IRAK-4, recently found another IRAK family member necessary for the IL-1 pathway, is able to phosphorylate IRAK in vitro sμ ggests that IRAK-4 might be the IRAK kinase.
IRAK4 is required for the efficient recruitment of IRAK to the IL-1 receptor complex.

Monoclonal

Wet Ice