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Anti-Neurofilament L (NF-L)

Anti-Neurofilament L (NF-L)

ArtNr	OAPC00027
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Antibodies Western Blot Immunofluorescence Primary Antibodies Neurodegeneration Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Chicken (Gallus gallus domesticus), Cow (Bos taurus)
Host	Chicken
Citations	1.Harris, J., Ayyub, C. and Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res 30:47-62. 2. Mersiyanova IV, Perepelov AV, Polyakov AV, Sitnikov VF, Dadali EL, Oparin RB, Petrin AN and Evgrafov OV. (2000) A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 67:37-46.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	NFL,NF-L,NF68,CMT1F,CMT2E,CMTDIG,PPP1R110
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	~68kDa
Manufacturer - Application Additional Information	WB: 1:10000IF: 1:5000
Gene symbol	NEFL
Product format	Liquid with 10mM sodium azide. Adequate amount of material to conduct 10 mini Western blots.
Reconstitution and storage	Store at -20°C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Description of target	Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H (1). NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease (2).
Protein accession_num	NP_776546.1
Protein name	Neurofilament light polypeptide
Clonality	Polyclonal
Purification	Total IgY fraction.
Immunogen	Preparation of bovine spinal cord intermediate filaments
Homology	Cow; Human; Mouse; Rat
Manufacturer - Specificity	Specific for the ~68k Neurofilament L protein in Western blots and works well on frozen sections, cells in tissue culture and on mildly formalin fixed histological sections.
Concentration	Varies by lot. See vial for concentration.

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