Anti-Park7 (DJ-1)

ArtNr	OAPC00050
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Neuroinflammation Neural Mitochondrial Function Neural Transcription Factors Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Neural Development Antibodies Western Blot Immunofluorescence Primary Antibodies Glial Cell Markers
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF
Clon	4H4
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Cow (Bos taurus)
Host	Mouse
Isotype	IgG1
Citations	Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. Jan 10;299(5604):256-9 Wang Z, Zhang Y, Zhang S, Guo Q, Tan Y, Wang X, Xiong R, Ding J, Chen S. (2011) DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. Mol Neurodegener. Jun 6;6:38
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Dj1,CAP1,DJ-1,SP22
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Monoclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	IgG¹
Shipping Temperature	Wet Ice
Molecular Weight	~21kDa
Manufacturer - Application Additional Information	The antibody has been directly tested for reactivity in bovine, human, mouse and rat. It is expected that it will work on other mammalian tissues. Western blot of rat kidney lysate showing specific immunolabeling of the ~21k park7 protein. Immunofluorescence of HeLa cells stained with anti-park7 (green) showing strong cytoplasmic staining and anti-vimentin antibody (catalog #OAPC00084) (red).
Gene symbol	PARK7
Product format	Liquid. 100 ul in PBS + 10 mM sodium azide
Reconstitution and storage	Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Description of target	Park7, also known as DJ-1, is a member of the peptidase C56 family of proteins and is thought to function as a molecular chaperone. Mutations in park7 have been associated with autosomal recessive, early onset Parkinson's disease (Bonifati et al., 2003). Recently, park7 has been shown to inhibit microtubule associated protein 1B aggregation thus leading to neuronal apoptosis (Wang et al., 2011).
Protein accession_num	NP_001264179.1
Protein name	Protein DJ-1
Clonality	Monoclonal
Purification	Affinity purified from tissue culture supernatant.
Immunogen	Full length recombinant human park7 expressed in and purified from E. coli.
Homology	Cow; Human; Mouse; Rat
Manufacturer - Specificity	Specific for the ~21k park7 protein.

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