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Anti-Doublecortin (DCX)

Anti-Doublecortin (DCX)

ArtNr	OAPC00106
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies Cell Biology Cytoskeleton Western Blot Immunofluorescence Primary Antibodies Intermediate filaments Microglia Markers Stem Cell Markers
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF
Clon	30
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Cattle (Bovine)
Host	Mouse
Isotype	IgG2a
Citations	Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG (2003) Transient expression of doublecortin during adult neurogenesis. J Comp Neurol. Dec 1;467(1):1-10. des Portes V, Pinard JM, Billuart P, Vinet MC, Koulakoff A, Carri&Ã‚Â© A, Gelot A, Dupuis E, Motte J, Berwald-Netter Y, Catala M, Kahn A, Beldjord C and Chelly J. (1998) A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Cell 92:51-61. Gleeson JG, Allen KM, Fox JW, Lamperti ED, Berkovic S, Scheffer I, Cooper EC, Dobyns WB, Minnerath SR, Ross ME and Walsh CA. (1998) Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell 92:63-72.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	DC,DBCN,LISX,SCLH,XLIS
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Monoclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: 1:5000 IF: 1:1000
Gene symbol	DCX
Gene Fullname	Doublecortin
Product format	Liquid PBS + 10 mM sodium azide. Adequate amount of material to conduct 10-mini Western blots
Reconstitution and storage	Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Description of target	Doublecortin, or DCX, is a microtubule associated protein that is expressed almost exclusively in very early neuronal development (Brown et al., 2003), making it an excellent marker for developing neuronal cells. Defects in the DCX gene lead to X-linked lissencephaly which is characterized by a lack of normal folds on the surface of the brain resulting in a smooth cerebral cortex caused by abnormal migration of neurons during development (des Portes et al., 1998; Gleeson et al., 1998).
Protein accession_num	NP_000546.2
Protein name	Neuronal migration protein doublecortin
Clonality	Monoclonal
Purification	Affinity purified from tissue culture supernatant.
Immunogen	Full length recombinant human doublecortin expressed in and purified from E. coli.
Manufacturer - Specificity	Specific for the ~35 & 45 k doublecortin protein.
Concentration	1 mg/ml

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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