Sptan1 Antibody

ArtNr	OAPC00143
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Western Blot Immunofluorescence Primary Antibodies Neurodegeneration Markers
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF
Clon	3D7
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus), Cow (Bos taurus)
Host	Mouse
Isotype	IgG1
Citations	Bennett V & Baines AJ.(2001) Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev. 81:1353-92. Eber S & Lux SE. (2004) Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. Semin Hematol 41:118-41.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	A2a,IPF,Spna2
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Monoclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	IgG¹
Shipping Temperature	Wet Ice
Molecular Weight	~240kDa
Manufacturer - Application Additional Information	The antibody has been directly tested for reactivity in bovine, human and rat. Western blot of rat hippocampal lysate showing specific immunolabeling of the ~240k alpha II spectrin protein. Immunofluorescence of cultured rat neurons and glia showing axonal and dendritic staining of alpha II spectrin (green) revealing the submembraneous cytoskeleton and DNA (blue).
Gene symbol	SPTAN1
Gene Fullname	Spectrin alpha chain, non-erythrocytic 1
Product format	Liquid. 100 ul in PBS + 10 mM sodium azide
Reconstitution and storage	Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
Description of target	The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (alpha 1 and alpha 2) and five beta genes (beta 1- beta 5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).
Nucleotide accession_num	NM_171983.2
Protein accession_num	NP_741984.2
Protein name	Spectrin alpha chain, non-erythrocytic 1
Clonality	Monoclonal
Purification	Affinity purified from tissue culture supernatant.
Immunogen	Recombinant construct containing the seventh, eighth and ninth repeats of human alpha II spectrin expressed in and purified from E. Coli.
Homology	Cow; Human; Rat
Manufacturer - Specificity	Specific for the ~240 k alpha II spectrin protein.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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OAPC00143-datasheet.pdf

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Menge: 100 ul

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Lieferung vsl. bis 29.01.2026

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