PRDM1 Antibody

ArtNr	OARA03181
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Antibodies By Cell Type Carcinoma Sarcoma Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies CHiP By Organ Breast Cancer Heart & Blood Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, IHC, ELISA, CHIP
Specific against	Human (Homo sapiens)
Host	Rabbit
Konjugat/Tag	Unconjugated
Dry ice	Yes
Citations	Morris AC, Beresford GW, Mooney MR, and Boss JM. (2002) Kinetics of a Gamma Interferon Response: Expression and Assembly of CIITA Promoter IV and Inhibition by Methylation Mol Cell Biol, 22 (13) 4781-4791.Fujita, N., D.L. Jaye, C. Geigerman, A. Akyildiz, M.R. Mooney, J.M. Boss, and P.A. Wade. 2004. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell. 119:75-86. Nagy M., Chapuis B., Matthes T. (2002) Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells.; Br. J. Haematol. 116:429-435.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	B lymphocyte induced maturation protein;B lymphocyte-induced maturation protein 1;b2b1765C;b2b1765Clo;beta-interferon gene positive regulatory domain I-binding factor;beta-interferon gene positive-regulatory domain I binding factor;Bli;Blim;BLIMP1;BLIMP-1;B-lymphocyte-induced maturation protein 1;PR domain 1;PR domain containing 1,with ZNF domain;PR domain zinc finger protein 1;PR domain-containing protein 1;PRDI-;PRDI-BF1;PRDI-binding factor-1;ZNFPR1A1.
Similar products	PRDM1
Versandbedingung	Trockeneis
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies, Root Catalog/Research Areas/Cancer/Cancer Transcription Factor
Shipping Temperature	Dry Ice
Molecular Weight	88 kDa
Manufacturer - Application Additional Information	ELISA 1:20000~40000 IP 5-10 ug/mL WB 1:1000 IHC-P 5 ug/ml This affinity purified antibody has been tested for use in ELISA, Immunohistochemistry, and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~88 kDa in size corresponding to BLIMP1 by western blotting in the appropriate cell lysate or extract.
Gene symbol	Prdm1\|PRDM1
Gene Fullname	PR domain containing 1, with ZNF domain\|PR/SET domain 1
Product format	Liquid (sterile filtered)
Reconstitution and storage	Store vial at -20C or below prior to opening. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20C or below. Avoid cycles of freezing and thawing. This product is stable at 4C for several weeks as an undiluted liquid. Expiration date is one (1) year from date of opening.
Description of target	Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484).
Protein name	PR domain zinc finger protein 1
Clonality	Polyclonal
Purification	The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
Immunogen	Anti-Blimp1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of human, mouse, and rat PRDM1/BLIMP1.
Manufacturer - Specificity	This antibody is predicted to react with BLIMP1 and its isoforms from human, mouse, rat and other sources based on a 100% homology with the immunizing sequence. This antibody may also recognize other proteins that show high homology/identity with the BLIMP1 sequence.
Concentration	1 mg/ml

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Menge: 100 ug

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