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NEDD4L Antibody - middle region

NEDD4L Antibody - middle region

ArtNr	ARP43192_P050
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Metabolism Diabetes Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies Western Blot Primary Antibodies Neurodegeneration Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Guinea Pig, Dog (Canine, Canis lupus familiaris), Horse (Equine), Zebrafish (Danio rerio), Cow (Bos taurus)
Host	Rabbit
Sequence	TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLP
Citations	Raikwar,N.S. Am. J. Physiol. Renal Physiol. 294 (5), F1157-F1165 (2008)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	RSP5,PVNH7,NEDD4-2,NEDD4.2,hNEDD4-2
Similar products	NEDD4L
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Research Areas/E3 & Ubiquitin, Root Catalog/Research Areas/Membrane & Traffic, Root Catalog/Products/Polyclonal Antibodies/Trial Size Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Enhanced Validation Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies, Root Catalog/Products/Aviva Rabbit Polyclonal
Shipping Temperature	Wet Ice
Molecular Weight	110 kDa
Species Tested	Human
Gene symbol	NEDD4L
Gene Fullname	Neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Protein size	955
Product format	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and storage	For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Partner proteins	NEDD4L; DAZAP2; UBE2D1; PTCH1; WNK3; TNK2; SNCA; SLC9A3; SMAD6; KCNH2; HCN1; SMAD3; UBE2N; SNA3; NOTCH1; UBE2D3; UBC; SGK1; KCNQ1; SGK3; GORAB; MED28; FBXL15; vpr; RNF11; AATF; YWHAQ; LAPTM5; SCNN1B; SMAD2; ARRDC3; ARRDC4; UBE2L3; UBE2D2; SMAD7; UBE2K; UB
Description of target	NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
Nucleotide accession_num	NM_015277
Protein accession_num	NP_056092
Protein name	E3 ubiquitin-protein ligase NEDD4-like
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	The immunogen is a synthetic peptide directed towards the middle region of human NEDD4L
Homology	Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Concentration	0.5 mg/ml

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Menge: 100 ul

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