GAD2 Antibody - N-terminal region

Polyclonal Antibody

Wet Ice

Human

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

NP_000809.1

Polyclonal

The immunogen is a synthetic peptide directed towards the N terminal region of human GAD2