MAP3K3 Antibody (OAAH00044)

Mitogen-activated protein kinase kinase kinase 3

74 kDa

This gene product is a 657-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB) -dependent reporter gene, consistent with a role in the SAPK pathway.

This Aviva monoclonal antibody is produced by immunizing mice with a polypeptide (Aviva SEAL mAb technology) corresponding to surface multi-epitopes of human MEKK3.