ATG4A Antibody

ArtNr	OAAF03545
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Neuroscience Neural Lineage Markers Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Autophagy Primary Antibodies Immunostaining Glial Cell Markers Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Citations	Marino G., J. Biol. Chem. 278:3671-3678(2003). Kabeya Y., J. Cell Sci. 117:2805-2812(2004). Ross M.T., Nature 434:325-337(2005
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	APG4 autophagy 4 homolog A;APG4A;ATG4 autophagy related 4 homolog A;AUTL2;AUT-like 2 cysteine endopeptidase;AUT-like 2,cysteine endopeptidase;autophagin 2;Autophagin-2;autophagy-related cysteine endopeptidase 2;autophagy-related protein 4 homolog A;cysteine protease ATG4A;hAPG4A.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunocytochemistry\|Immunofluorescence\|Immunohistochemistry\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	45 kDa
Manufacturer - Application Additional Information	IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:20000
Gene symbol	ATG4A
Gene Fullname	autophagy related 4A cysteine peptidase
Product format	Liquid
Reconstitution and storage	-20°C
Description of target	Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Protein accession_num	NP_443168.2
Protein name	Cysteine protease ATG4A
Clonality	Polyclonal
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen	The antiserum was produced against synthesized peptide derived from human ATG4A.
Dilution	The optimal working dilution should be determined by the end user.
Manufacturer - Specificity	ATG4A antibody detects endogenous levels of total ATG4A protein.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Menge: 100 ug

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Lieferung vsl. bis 27.11.2025

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