RAP80 Antibody

ArtNr	OAPB00570
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Epigenetics Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies By Organ Breast Cancer Thyroid Cancer Immunostaining Macrophage Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Pig (Porcine, Sus scrofa domesticus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Yan Z, Kim YS, and Jetten AM. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. J. Biol. Chem.2002; 277:32379-88.;Wang B, Matsuoka S, Balliff BA, et al. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science2007; 316:1194-1198.;Kim H, Huang J, and Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat. Struct. Mol. Biol.2007; 14:710-5.;Liu Z, Wu J, and Yu X. CCDC98 targets BRCA1 to DNA damage sites. Nat. Struct. Mol. Biol.2007; 14:716-20.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BRCA1-A complex subunit RAP80;RAP80;receptor-associated protein 80;retinoid X receptor-interacting protein 110;Ubiquitin interaction motif-containing protein 1;X2HRIP110.
Similar products	RAP80
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	RAP80 antibody can be used for detection of RAP80 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	UIMC1
Gene Fullname	ubiquitin interaction motif containing 1
Product format	Liquid. RAP80 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	RAP80 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/EAW85043
Protein name	BRCA1-A complex subunit RAP80\|receptor associated protein 80, isoform CRA_c [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	RAP80 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human RAP80. The immunogen is located within amino acids 30 - 80 of RAP80.
Homology	Human; Mouse
Concentration	1 mg/ml

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Menge: 0.1 mg

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Lieferung vsl. bis 27.11.2025

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