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NFKBIA Antibody (Phospho-Tyr42)

ArtNr OAAF00337
Hersteller AVIVA Systems Biology
Menge 100 ug
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen WB, IF, IHC, ELISA
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Citations Béraud C, et al. (1999) Proc Natl Acad Sci U S A 96(2): 429-434.
Sundström S, et al. (2005) J Virol 79(4): 2230-2239.
Liu L, et al. (1998) Mol Cell Biol 18(7): 4221-4234.
Shrivastava A, et al. (1998) J Virol 72(12): 9722-9728.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias EDAID2;IkappaBalpha;I-kappa-B-alpha;IKBA;ikB-alpha;MAD-3;major histocompatibility complex enhancer-binding protein MAD3;NF-kappa-B inhibitor alpha;NFKBI;nuclear factor of kappa light chain gene enhancer in B-cells;nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha.
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Polyclonal Antibody
Manufacturer - Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Manufacturer - Category
Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Phospho Specific, Root Catalog/Products/Primary Antibodies
Shipping Temperature
Wet Ice
Molecular Weight
35 kDa
Manufacturer - Application Additional Information
IHC: 1:50~1:100; ELISA: 1:10000
Gene symbol
NFKBIA
Gene Fullname
NFKB inhibitor alpha
Product format
Liquid
Reconstitution and storage
-20°C
Description of target
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Protein accession_num
NP_065390.1
Protein name
NF-kappa-B inhibitor alpha
Clonality
Polyclonal
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
The antiserum was produced against synthesized peptide derived from human IkappaB-alpha around the phosphorylation site of Tyr42.
Dilution
The optimal working dilution should be determined by the end user.
Manufacturer - Specificity
IκB-α (phospho-Tyr42) antibody detects endogenous levels of IκB-α only when phosphorylated at tyrosine 42.
Formulation
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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