COPS3 Antibody

ArtNr	OAAF01839
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Targets for Rodent Neurosciences Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies Astrocytoma By Organ Bladder Cancer Breast Cancer Immunostaining Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Citations	George Z. Rassidakis, Clin. Cancer Res., Mar 2003; 9: 1121. Ricardo V. Lloyd, Am. J. Pathol., Mar 2002; 160: 1171. Shu Xiao, PNAS, Oct 2006; 103: 16448 - 16453. Alex Kudrin, J. Biol. Chem., Oct 2006; 281: 29641 - 29651.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	COP9 complex subunit 3;COP9 constitutive photomorphogenic homolog subunit 3;COP9 signalosome complex subunit 3;CSN3;JAB1-containing signalosome subunit 3;SGN3;signalosome subunit 3.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunocytochemistry\|Immunofluorescence\|Immunohistochemistry\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	47 kDa
Manufacturer - Application Additional Information	WB: 1:500~1:3000; IF: 1:100~1:500; ELISA: 1:5000
Gene symbol	COPS3
Gene Fullname	COP9 signalosome subunit 3
Product format	Liquid
Reconstitution and storage	-20°C
Description of target	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Protein accession_num	NP_001186054.1
Protein name	COP9 signalosome complex subunit 3
Clonality	Polyclonal
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen	The antiserum was produced against synthesized peptide derived from human JAB1.
Dilution	The optimal working dilution should be determined by the end user.
Manufacturer - Specificity	JAB1 antibody detects endogenous levels of total JAB1 protein.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Menge: 100 ug

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Lieferung vsl. bis 29.01.2026

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