APOOL Antibody

ArtNr	OAAF03292
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Adult-onset obesity is triggered by impaired mitochondrial gene expression. Sci Adv. 3, e1700677 (2017). 28835921 QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Elife. 4, (2015). 25997101 QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease. Elife. 5, (2016). 27623147 Clark H.F., Genome Res. 13:2265-2270(2003). Ross M.T., Nature 434:325-337(2005). The MGC Project Team; Genome Res. 14:2121-2127(2004).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AAIR8193;Apolipoprotein O-like;CXorf33;FAM121A;family with sequence similarity 121A;Mic27;MICOS complex subunit MIC27;MICOS27;mitochondrial contact site and cristae organizing system subunit 27;Protein FAM121A;UNQ8193.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	29 kDa
Manufacturer - Application Additional Information	WB 1:500~1000 ELISA 1:40000
Gene symbol	APOOL
Gene Fullname	apolipoprotein O like
Product format	Liquid. PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reconstitution and storage	-20°C
Description of target	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).
Protein accession_num	NP_940852.3
Protein name	MICOS complex subunit MIC27
Clonality	Polyclonal
Purification	The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Immunogen	The antiserum was produced against synthesized peptide derived from human APOOL.
Dilution	The optimal working dilution should be determined by the end user.
Manufacturer - Specificity	APOOL antibody detects endogenous levels of total APOOL protein.
Concentration	1 mg/ml

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Menge: 100 ug

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Lieferung vsl. bis 29.01.2026

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