Anti-Tubulin-gamma Polyclonal Antibody (OAAI00012)

TUBG1

7283

Tubulin gamma, a member of the tubulin superfamily, is a ubiquitous and highly conserved protein within the microtubule organizing centre (MTOC). It is an essential structural protein for cell growth organizes microtubule arrays in the nucleus and cytoplasm. Tubulin gamma-depleted cells fail to form functional spindles and arrest during nuclear division. The phosphorylation of Tubulin gamma at Tyr445 plays a regulatory role in microtubule formation. The incidence Rate for this phosphorylation event peaks during G1. The abundance of Gamma tubulin is less than 1% of the level of either alpha or beta tubulin. It shares approximately 28-32% identity with alpha tubulin from various organisms and 32-36% identity with beta tubulins. The detection, localization and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis and the microtubule cytoskeleton. Antibodies reacting specifically with gamma tubulin serve as an essential tool in the detection of the presence and role of this molecule in various cellular settings. Gamma tubulin 1 and Gamma tubulin 2 are different isoforms that are 97% homologous.

Polyclonal

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