Anti-PDGF Polyclonal Antibody (OAAI00223)

Wet Ice

CASP1

The platelet-derived growth factor (PDGF) family of disulfide-linked dimeric proteins consists of homo/hetero dimeric proteins, PDGF-AA, -BB, -CC, -DD and -AB. The PDGF-AA, -BB and AB bind to alpha type receptor, while beta type receptors bind to PDGF-BB and PDGF-AB. Upon activation by PDGF, the receptors get dimerised and auphosphorylated in several sites on its receptors (Receptor tyrosine kinase) in cytosolic domain to trigger cell signaling throμ gh PI3K pathway.
All PDGF isoforms are synthesized as inactive precursors and are processed to active forms.

The Rabbit IgG is purified by Epitope Affinity Purification.