Anti-TAFA2 Antibody (OAAI00405)

ca.12 kDa

338811

The TAFA2, also known as FAM19A2, is a secreted 12kDa protein. It belongs to the FAM19/TAFA family of chemokinelike. The family is composed of five highly homologous genes referred to as TAFA-1 to -5. The TAFA genes encode proteins of approximately 100 amino acids that contain conserved cysteine residues at fixed positions. TAFA-1 to -4 are more closely related to each other than to TAFA-5, in which a conserved motif including CC in TAFA-1 to -4 is not present. In H. sapiens, TAFA-3 has two isoforms formed by alternative splicing. TAFAs are highly expressed in central nervous system (CNS), and less extent in other tissues such as colon, heart, lung, spleen, kidney, and thymus. TAFA2 is expression is highest in the occipital and frontal cortex. TAFAs may modulate immune responses in the CNS by functioning as brainspecific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. It may act as neurokines that regulates immune nervous cells . It may also control axonal sprouting following brain injury.

Polyclonal

Wet Ice