GDF6 Antibody

ArtNr	OAPB00713
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Food Safety Proteins Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Western Blot ELISA Primary Antibodies Immunostaining Glial Cell Markers Neuron Nuclear Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Cattle (Bovine)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol.6:597-641.;McPherron AC, Lawler AM, and Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature1997; 387:83-90.;Hanel ML and Hensey C. Eye and neural defects associated with loss of GDF6. BMC Dev. Biol.2006; 6:43.;Settle SH Jr., Rountree RB, Sinha A, et al. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev. Biol.2003; 254:116-130.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BMP13;BMP-13;bone morphogenetic protein 13;CDMP2;growth/differentiation factor 16;growth/differentiation factor 6;KFM;KFS;KFS1;KFSL;SGM1;SYNS4.
Similar products	GDF6
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	GDF6 antibody can be used for detection of GDF6 by Western blot at 1 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	GDF6
Gene Fullname	growth differentiation factor 6
Product format	Liquid. GDF6 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	GDF6 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_001001557
Protein name	Growth/differentiation factor 6\|growth/differentiation factor 6 preproprotein [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	GDF6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human GDF6. The immunogen is located within amino acids 320 - 370 of GDF6.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

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Menge: 0.1 mg

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