TNFAIP3 Antibody - middle region (OAPB00877)

TNFAIP3

Liquid. Antibody is supplied in PBS containing 0.02% sodium azide.

TNFAIP3, also known as A20, is located in chromosome band 6q23, a region that is often deleted in B cell lymphomas. Recently, it was identified as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas. TNFAIP3 was initially identified as a zinc-finger protein that is rapidly and transiently induced by TNF-alpha, inhibiting NF-kappaB-dependent gene expression, and protecting cells from TNF-alpha-cytotoxicity. Overexpression of TNFAIP3 also inhibits the TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, suggesting that TNFAIP3 also acts as a negative regulator of TLR-mediated inflammatory responses, thereby protecting the host against harmful over-responses to pathogens. At least two isoforms of TNFAIP3 are known to exist.

Affinity chromatography purified via peptide column

The immunogen for anti-TNFAIP3 antibody: antibody was raised against a 17 amino acid peptide near the center of human TNFAIP3.