Girdin Antibody

ArtNr	OAPB01016
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Adenocarcinoma Mesothelioma Western Blot ELISA Immunofluorescence Autophagy Cardiovascular Research Proliferation Myocardial Infarction Primary Antibodies Astrocytoma Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Le-Niculescu H, Niesman I, Fischer T, et al. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J. Biol. Chem.2005; 280:22012-20.;Anai M, Shojima N, Katagiri H, et al. A novel protein kinase B (PKB)/Akt-binding protein enhances PKB kinase activity and regulates DNA synthesis. J. Biol. Chem.2005; 280:18525-35.;Enomoto A, Murakami H, Asai N, et al. Akt/PKB regulated actin organization and cell motility via Girdin/APE. Dev. Cell2005; 9:389-402. ;Enomoto A, Asai N, Namba T, et al. Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron2009; 63:774-87.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Akt phosphorylation enhancer;AKT-phosphorylation enhancer;APE;Coiled-coil domain-containing protein 88A;g alpha-interacting vesicle-associated protein;Girders of actin filament;girders of actin filaments;girdin;GIV;GRDN;HkRP1;Hook-related protein 1;KIAA1212;PEHO;PEHOL.
Similar products	Girdin
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	Girdin antibody can be used for detection of Girdin by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	CCDC88A
Gene Fullname	coiled-coil domain containing 88A
Product format	Liquid. Girdin Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	Girdin antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382).
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_060554
Protein name	Girdin\|girdin isoform 2 [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Girdin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus human Girdin. The immunogen is located within the last 50 amino acids of Girdin.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

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OAPB01016-datasheet.pdf

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Menge: 0.1 mg

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Lieferung vsl. bis 25.12.2025

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