PICALM Antibody

ArtNr	OAPB01019
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining Neurodegeneration Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Tebar F, Bohlander SK, and Sorkin A. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin mediated traffic. Mol. Biol. Cell1999; 10:2687-702.;Caudell D and Aplan PD. The role of CALM-AF10 gene fusion in acute leukemia. Leukemia2008; 22:678-85.;Harel A, Wu F, Mattson MP, et al. Evidence for CALM in directing VAMP2 trafficking. Traffic2008; 9:417-29.;Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimerâ€™s disease. Nat. Genet.2009; 41:1088-93.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CALM;clathrin assembly lymphoid myeloid leukemia protein;CLTH;LAP;phosphatidylinositol-binding clathrin assembly protein.
Similar products	PICALM
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	PICALM antibody can be used for detection of PICALM by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	PICALM
Gene Fullname	phosphatidylinositol binding clathrin assembly protein
Product format	Liquid. PICALM Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	PICALM antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_009097
Protein name	Phosphatidylinositol-binding clathrin assembly protein\|phosphatidylinositol-binding clathrin assembly protein isoform 1 [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	PICALM antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PICALM. The immunogen is located within the first 50 amino acids of PICALM.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

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Menge: 0.1 mg

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