TRESK Antibody

ArtNr	OAPB01021
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Food Safety Histamines Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Sano Y, Inamura K, Miyake A, et al. A novel two-pore K+ channel, TRESK, is localized in the spinal cord. J. Biol. Chem.2003; 278:27406-12.;Han J and Kang D. TRESK channel as a potential target to treat T-cell mediated immune dysfunction. Biochem. Biophys. Res. Comm.2009; 390:1102-5.;Czirjak G, Toth ZE, and Enyedi P. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. J. Biol. Chem.2004; 279:18550-8.;Huang DY, Yu BW, and Fan QW. Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia. Neurosci. Bull.2008; 24:166-72.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	K2p18.1;MGR13;potassium channel subfamily K member 18;potassium channel,subfamily K,member 18;potassium channel,two pore domain subfamily K,member 18;TRESK;TRESK2;TRESK-2;TRIK;TWIK-related individual K+ channel;TWIK-related individual potassium channel;TWIK-related spinal cord K+ channel;TWIK-related spinal cord potassium channel.
Similar products	TRESK
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
Gene symbol	KCNK18
Gene Fullname	potassium two pore domain channel subfamily K member 18
Product format	Liquid. TRESK Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	TRESK antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_862823
Protein name	Potassium channel subfamily K member 18\|potassium channel subfamily K member 18 [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	TRESK antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. The immunogen is located within amino acids 210 - 260 of TRESK.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

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