KPNA1 Antibody

ArtNr	OAPB01179
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies Immunostaining Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Cattle (Bovine)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene Expr.1997; 7:61-72.; Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem.2003; 278: 51937-49. ; Simkus C, Makiya M and Jones JM. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. Mol. Immunol.2009; 46:1319-25.; Reid SP, Valmas C, and Martinez O. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. J. Virol.2007; 81:13469-77.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	importin alpha 5;importin subunit alpha-1;importin subunit alpha-5;importin-alpha-S1;IPOA5;karyopherin alpha 1 (importin alpha 5);Karyopherin subunit alpha-1;NPI-1;nucleoprotein interactor 1;RAG cohort protein 2;RCH2;recombination activating gene cohort 2;SRP1;SRP1-beta.
Similar products	KPNA1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	KPNA1 antibody can be used for detection of KPNA1 by Western blot at 1 μ g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ g/mL. For immunofluorescence start at 20 μ g/mL. Optimal dilutions for each application to be determined by the researcher.
Gene symbol	KPNA1
Gene Fullname	karyopherin subunit alpha 1
Product format	Liquid. KPNA1 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	KPNA1 antibody can be stored at 4C for three months and-20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Description of target	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/NP_002255
Protein name	Importin subunit alpha-5\|importin subunit alpha-5 [Homo sapiens]
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	KPNA1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA1. The immunogen is located within amino acids 30 - 80 of KPNA1.
Homology	Human; Mouse; Rat
Concentration	1 mg/ml

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Menge: 0.1 mg

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Lieferung vsl. bis 30.10.2025

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