Anti-COBRA 1

ArtNr	OAPC00093
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Western Blot Primary Antibodies By Organ Bladder Cancer Breast Cancer Neuronal Cell Markers
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB
Clon	F7E4
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1
Citations	Aiyar, SE, Sun J, Blair AL, Moskaluk CA, Lu Y, Ye Q, Yamaguchi Y, Mukherjee A, Ren D, Handa H, Li R (2004). Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev. 18 (17): 2134-46. Zhong, H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Qi (2004). COBRA1 inhibits AP-1 transcriptional activity in transfected cells. Biochem. Biophys. Res. Commun.325 (2): 568-73.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	COBRA1,NELF-B
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Monoclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	IgG¹
Shipping Temperature	Wet Ice
Molecular Weight	~62kDa
Manufacturer - Application Additional Information	The antibody has been directly tested for reactivity in Western blots with human, mouse and rat tissue. Western blot of neonatal rat brain lysate showing specific immunolabeling of the ~ 62K COBRA1 protein.
Gene symbol	COBRA1
Product format	Liquid. 100 ul in PBS + 0.05 % NaN3. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and storage	Store at -20C; stable for at least one year.
Description of target	COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ER alpha) and repress ER alpha -mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogeneis (Zhong H et al., 2004)
Nucleotide accession_num	NM_015456
Protein accession_num	NP_056271
Protein name	Negative elongation factor B
Clonality	Monoclonal
Purification	Protein G purified culture supernatant.
Immunogen	Recombinant full length human COBRA1 purified from E. coli
Homology	Human; Mouse; Rat
Manufacturer - Specificity	Specific for the ~62k COBRA1 protein in Western blots of neonatal rat brain lysate.

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Menge: 100 ul

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Lieferung vsl. bis 11.12.2025

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