PMEPA1 Antibody

ArtNr	OAAF02602
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Antibodies By Cell Type Carcinoma Adenocarcinoma Immunohistochemistry Western Blot ELISA Immunofluorescence Immunocytochemistry Primary Antibodies By Organ Colorectal Cancer Immunostaining Neurodegeneration Markers Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Xu L.L., Genomics 66:257-263(2000). Rae F.K., Mol. Carcinog. 32:44-53(2001). Deloukas P., Nature 414:865-871(2001).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Prostate transmembrane protein androgen induced 1;protein TMEPAI;solid tumor-associated 1 protein;STAG1;TMEPAI;Transmembrane prostate androgen-induced protein;transmembrane,prostate androgen induced RNA.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunocytochemistry\|Immunofluorescence\|Immunohistochemistry\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	31 kDa
Manufacturer - Application Additional Information	WB: 1:500~1000 IHC: 1:50~100 IF: 1:100~500 ELISA: 1:20000
Gene symbol	PMEPA1
Gene Fullname	prostate transmembrane protein, androgen induced 1
Product format	Liquid PBS (without Mg²⁺ and Ca²⁺) (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol
Reconstitution and storage	-20°C
Description of target	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
Protein accession_num	NP_001242905.1
Protein name	Protein TMEPAI
Clonality	Polyclonal
Purification	The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Immunogen	The antiserum was produced against synthesized peptide derived from human TMEPA.
Dilution	The optimal working dilution should be determined by the end user.
Manufacturer - Specificity	TMEPA antibody detects endogenous levels of total TMEPA protein.
Concentration	1 mg/ml

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Menge: 100 ug

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Lieferung vsl. bis 12.02.2026

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