ENG Antibody

ArtNr	OAAF08251
Hersteller	AVIVA Systems Biology
Menge	0.05 ml
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Glucose Homeostasis Molecular Targets for Neuroscience Neural Signaling Neural Development Antibodies By Cell Type Carcinoma Cell Biology Cell Culture Cytokines Mesothelioma Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody Monoclonal
Applikationen	IHC
Clon	ABT-CD105
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD105 antigen;END;endoglin;HHT1;ORW1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	70 kDa
Species Tested	Human
Manufacturer - Application Additional Information	IHC 1:200 - 1:400
Gene symbol	ENG
Gene Fullname	endoglin
Product format	PBS, pH7.2, 0.03% Proclin 300, 50% glycerol
Reconstitution and storage	-20°C
Description of target	Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Nucleotide accession_num	NM_000118.3
Protein accession_num	NP_000109.1ï»¿
Protein name	Endoglin
Clonality	Monoclonal
Purification	Immunogen affinity purified
Immunogen	Synthetic peptide.
Manufacturer - Specificity	Anti-CD105 (Endoglin) [ABT-CD105] detects endogenous levels of total CD105 (Endoglin) protein.

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OAAF08251-datasheet.pdf

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Menge: 0.05 ml

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Lieferung vsl. bis 29.01.2026

Express-Lieferung: 20 Tage sparen

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