BSG Antibody

ArtNr	OAEE00089
Hersteller	AVIVA Systems Biology
Menge	0.1 mg (C100)
Kategorie	Oncology Metabolism Glucose Homeostasis Antibodies By Cell Type Carcinoma Hematology Lymphoma Flow Cytometry Western Blot Primary Antibodies Functional Assays
Typ	Antibody Monoclonal
Applikationen	WB, FC, FA
Clon	MEM-M6/6
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Koch C, Staffler G, Huttinger R, Hilgert I, Prager E, Cerny J, Steinlein P, Majdic O, Horejsi V, Stockinger H: T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density. Int Immunol. 1999 May;11(5):777-86. Schmidt R, BÃ¼ltmann A, Fischel S, Gillitzer A, Cullen P, Walch A, Jost P, Ungerer M, Tolley ND, Lindemann S, Gawaz M, SchÃ¶mig A, May AE. Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor onplatelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes. Circ Res. 2008 Feb 15;102(3):302-9. Melchior A, Denys A, Deligny A, Mazurier J, Allain F: Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activatedprotein kinases. Exp Cell Res. 2008 Feb 1;314(3):616-28. Ruiz S, Castro-Castro A, Bustelo XR: CD147 Inhibits the Nuclear Factor of Activated T-cells by Impairing Vav1 and Rac1 Downstream Signaling. J Biol Chem. 2008 Feb 29;283(9):5554-66. Iacono KT, Brown AL, Greene MI, Saouaf SJ: CD147 immunoglobulin superfamily receptor function and role in pathology. Exp Mol Pathol. 2007 Dec;83(3):283-95. Xu D, Hemler ME: Metabolic activation-related CD147-CD98 complex. Mol Cell Proteomics. 2005 Aug;4(8):1061-71. Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP: Basigin (CD147) is the target for organomercurial inhibition of monocarboxylatetransporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem. 2005 Jul 22;280(29):27213-21. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP: CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000 Aug 1;19(15):3896-904.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	5F7;basigin;CD147;collagenase stimulatory factor;EMMPRIN;EMPRIN;extracellular matrix metalloproteinase inducer;HAb18G;hepatoma-associated antigen;leukocyte activation antigen M6;OK;OK blood group antigen;SLC7A11;TCSF;tumor cell-derived collagenase stimulatory factor.
Similar products	CD147
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	BSG
Gene Fullname	basigin (Ok blood group)
Product format	Phosphate buffered saline (PBS), pH 7.4
Reconstitution and storage	2°C to 8°C
Description of target	Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
Nucleotide accession_num	NM_001728.3; NM_198589.2; NM_198590.2; NM_198591.2; XM_005259619.1
Protein accession_num	NP_001719.2; NP_940991.1; NP_940992.1; NP_940993.1; XP_005259676.1
Protein name	Basigin
Clonality	Monoclonal
Purification	Purified
Immunogen	Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimmer).
Manufacturer - Specificity	The antibody MEM-M6/6 recognizes Ig domain D2 (membrane proximal) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes.
Formulation	Low endotoxin
Concentration	1 mg/ml
Storage Buffer	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

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Menge: 0.1 mg (C100)

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