IGF1R Antibody

ArtNr	OASA01598
Hersteller	AVIVA Systems Biology
Menge	0.5 mg
Kategorie	Oncology Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies By Cell Type Sarcoma Cell Biology Cell Culture Cytokines Flow Cytometry Immunohistochemistry Western Blot Endocrine Regulation of Lipid Metabolism Primary Antibodies Functional Assays
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, FC, IHC, FA
Clon	1H7
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Citations	1. Li, S.L. et al. (1993) Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor. Biochem. Biophys. Res. Commun. 196:92-98.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	IGFR,CD221,IGFIR,JTK13
Similar products	IGF1R
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Functional assay\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Growth Factors & Hormones, Root Catalog/Research Areas/Cell Biology, Root Catalog/Research Areas/Developmental Biology, Root Catalog/Research Areas/Immunology, Root Catalog/Research Areas/Signal Transduction, Root Catalog/Research Areas/Apoptosis, Root Catalog/Research Areas/Phosphorylation, Root Catalog/Research Areas/Flow Cytometry Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Conjugate / Tag	LE: Low Endotoxin
Shipping Temperature	Wet Ice
Molecular Weight	~155 kDa
Manufacturer - Application Additional Information	FC: 1/10. Use 10 uL of the suggested working dilution to label 106 cells in 100 uL.IHC-P: 1/10 - 1/40. This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
Gene symbol	IGF1R
Protein size	1367
Product format	Liquid. Phosphate buffered saline
Reconstitution and storage	-20°C
Description of target	CD221 is a receptor tyrosine kinase. CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting. CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.
Protein accession_num	NP_000866.1
Protein name	Insulin-like growth factor 1 receptor
Clonality	Monoclonal
Purification	Protein G Purified
Immunogen	Purified human placental IGF-I receptor.
Homology	Human
Manufacturer - Specificity	CD221. The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signaling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221.
Concentration	1 mg/ml

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Menge: 0.5 mg

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