EPCAM Antibody: Azide Free

Monoclonal Antibody

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Wet Ice

EPCAM

Liquid. Phosphate buffered saline

MOUSE ANTI HUMAN CD326:Azide Free

Epithelial cell adhesion molecule

Antibody purified from tissue culture supernatant

This antibody recognises the 40kDa cell surface antigen known as CD326. This antigen has been identified independently by a number of groups, and it has been known by a variety of names including Epithelial Cell Adhesion Molecule (Ep-CAM), Epithelial Specific Antigen, MOC31 and Ber-EP4. Several monoclonal antibodies have been raised against CD326, many of which have been described as tumour specific molecules on carcinomas. CD326 is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. CD326 expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium.